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Spinal muscular atrophy SMA is a genetic disease that results in progressive muscle weakness and paralysis. The condition occurs in 1 in 10, live births and affects both males and females. There are three types of SMA. The most severe type is usually diagnosed within the first few months of life.

Affected children have severe muscle weakness and typically do not survive past mkscular age of 2. The other two types of SMA, which are less common than the severe type, involve a lesser degree of muscle weakness.

Most affected individuals need to use wheelchairs or need assistance with walking. Life expectancy for the less severe types ranges from the teenage years to adulthood.

Those with the mildest form of SMA are expected to have a normal lifespan. There is no cure for SMA. Medical treatments for the milder forms of SMA may help extend the expected lifespan in gjrls cases.

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The great majority of babies with the most severe form of SMA do not survive past 2 years of age. SMA is a genetic condition. Our genes come in pairs, with one copy inherited from each parent.

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Some genes have mutations in them, and do not function properly. Someone with one non-functional copy of the gene is a carrier. Carriers for SMA have no symptoms, but can pass the non-functioning gene on to their children.

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If both parents are carriers there is a one in four 25 percent chance that both will pass on the non-functioning gene, which would result in a pregnancy affected with spinal muscular atrophy. Who should consider carrier testing for spinal muscular atrophy?

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Those who have a family member with SMA or a family member known to be a carrier are at increased risk to be a carrier themselves. Genetic counseling is recommended in these cases to determine the likelihood of having a pregnancy or child affected with SMA. An individual without a family history of SMA can be a carrier for this condition as well.

About 1 in 50 people, regardless of ethnic background, are carriers of the abnormal gene that causes SMA. Carrier testing is available through a simple blood test.

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The test can detect the most common mutation that is associated with SMA and will detect approximately 90 percent of carriers. A ggirls carrier test will greatly reduce the likelihood of having a child affected with this condition. There are gene changes mutations associated with SMA that are not included in the carrier test.

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In addition, in a small number of cases where a child is found to be affected, only one parent is a carrier. For both of these reasons, a negative carrier test cannot eliminate the possibility of having an affected child. What does it mean if I am a carrier for spinal muscular atrophy?

If you are found to be a carrier for SMA, your partner should undergo carrier testing as well. If your partner's test is negative, the chance to have an affected Sweet woman looking sex Keystone is low.

If your partner giels also found to be a carrier for SMA, there is a 1 in 4 25 percent chance of an affected pregnancy. Any muscular adult wives girls want free drinks from two parents with no family history of SMA are found to be carriers with routine screening, it is not possible to predict whether they are at risk of having children with the severe form of SMA or one of the less severe forms of SMA.

If both partners are carriers of SMA, prenatal testing is musular. Chorionic villus sampling CVS at 10 to 14 weeks or amniocentesis at 16 to 20 weeks can be performed to determine if the fetus has inherited two copies of the SMA gene mutation.

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If both partners are carriers and you are thinking of becoming pregnant, there are other options available. You can meet with a genetic counselor to discuss these issues.

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For more information about spinal muscular atrophy, genetic counseling or to arrange carrier or prenatal testing, contact the UCSF Prenatal Diagnostic Center at This information is for eant purposes only and is not intended to replace the advice of your doctor or health care provider.

We encourage you to discuss with your doctor any questions or concerns you may have.

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Prenatal Diagnostic Center Fourth St. Need a doctor? Call us at UCSF or browse our directory.

University of California San Francisco. MyChart Find a Doctor. Carrier Testing for Spinal Muscular Atrophy. Condition Information Pregnancy. Amniocentesis FAQ: Prenatal Tests Screening Tests.